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Dr. James Bradner

Amgen

Sarah-Jane Dawson, PhD

Peter MacCallum Cancer Centre

Denes Hnisz, PhD

Max Planck Institute for Molecular Genetics, Berlin, Germany

Florian Markowetz, PhD

University of Cambridge

Kamila Naxerova, PhD

Harvard Medical School

Ryan Notti, MD, PhD

The Rockefeller
University

Jeffrey Rathmell, PhD

Vanderbilt University Medical Center

Margaret A. Shipp, MD

Dana-Farber Cancer Institute

Jun Wang, PhD

Department of Pathology and the Laura and Isaac Perlmutter Cancer Center, NYU

E. John Wherry, PhD

University of Pennsylvania

Catherine J. Wu, MD

Dana-Farber Cancer Institute

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Breakfast

7:30 - 8:30 AM

Welcome and Mark Foundation Overview

8:30 - 9:00 AM

__________________________

Presented by:
Alex Knaster, Chairman & CEO, Pamplona Capital Management
Ryan Schoenfeld, PhD, CEO, The Mark Foundation

Session 1

9:00 - 10:15 AM

__________________________

9:00 AM: Circulating Tumour DNA to Serially Assess Genomic and Transcriptional Evolution in Cancer
Presented by:
Sarah-Jane Dawson, PhD, Medical Oncologist, Peter MacCallum Cancer Centre

9:25 AM: The Structural Biology of T-cell Receptor Activation
Presented by:
Ryan Notti, MD, PhD, Instructor in Clinical Investigation, The Rockefeller University

9:50 AM: Grand Challenges in Chromosomal Instability
Presented by:
Florian Markowetz, PhD, Professor of Computational Oncology, University of Cambridge

Fireside Chat

10:15 - 11:00 AM

__________________________

Dr. James Bradner, Executive Vice President, Research and Development, and Chief Scientific Officer, Amgen

Moderated by:
Ross Levine, MD, Chair Memorial Sloan Kettering Cancer Center

Break

11:00 - 11:15 AM

Session 2

11:15 - 12:30 PM

__________________________

11:15 AM: The Interplay Between Genetics and Tumor Microenvironment in Hodgkin Lymphoma
Presented by:
Margaret A. Shipp, MD, Professor of Medicine, Harvard Medical School, Dana-Farber Cancer Institute

11:40 AM: Transcriptional Condensates in Health and Disease
Presented by:
Denes Hnisz, PhD, Group Leader, Max Planck Institute for Molecular Genetics, Berlin, Germany

12:05 PM: A New Method for Driver-agnostic Detection of Clonal Expansions in Normal Tissues
Presented by:
Kamila Naxerova, PhD, Assistant Professor, Harvard Medical School

Lunch

12:30 - 1:30 PM

Keynote Lecture

1:30 - 2:30 PM

__________________________

Application of AI in Cancer Medicine

Presented by:

Regina Barzilay, MS, PHD, School of Engineering Distinguished Professor for AI and Health, The Massachusetts Institute of Technology

Session 3

2:30 - 3:20 PM

__________________________

2:30 PM: T-cell Exhaustion, Immunopharmacology, and Immunotherapy
Presented by:
John Wherry, PhD, Chair, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania

2:55 PM: The Obesity-Cancer Connection in Immunotherapy
Presented by:
Jeff Rathmell, PhD, Director, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center

Break

3:20 - 4:00 PM

Session 4

4:00 - 4:50 PM

__________________________

4:00 PM
Presented by:
Jun Wang, PhD, Assistant Professor, Department of Pathology and the Laura and Isaac Perlmutter Cancer Center, NYU

4:25 PM
Presented by:
Cathy Wu, MD, Chief, Division of Stem Cell Transplantation and Cellular Therapies,
Lavine Family Chair for Preventative Cancer Therapies, Professor of Medicine, Harvard Medical School

Closing Remarks

4:50 - 5:00 PM

__________________________

Raymond N. DuBois, MD, PhD, Executive Chairman of the Board, Medical University of South Carolina Hollings Cancer Center
Ryan Schoenfeld, PhD, CEO, The Mark Foundation

Reception

5:00 - 7:00 PM

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SYMPOSIUM LOCATION
Convene
117 West 46th Street, New York, NY 10036

Courtesy Room Blocks

Sofitel New York
45 West 44th Street
10036 New York

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Tempo New York
1568 Broadway Avenue
New York, NY 10036

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Muse Hotel New York
130 W. 46th Street
New York, NY 10036

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